John J Kopchick Selected Research

Somatotropin Receptors (Growth Hormone Receptor)

1/2022	GH Action in Prostate Cancer Cells Promotes Proliferation, Limits Apoptosis, and Regulates Cancer-related Gene Expression.
1/2022	First use of gene therapy to treat growth hormone resistant dwarfism in a mouse model.
12/2021	Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan.
1/2020	17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates.
3/2017	Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways.
1/2017	Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps.
1/2017	The role of transplanted visceral fat from the long-lived growth hormone receptor knockout mice on insulin signaling.
3/2016	Inflammatory and Glutamatergic Homeostasis Are Involved in Successful Aging.
3/2015	Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver.
2/2015	Growth hormone receptor antagonist transgenic mice are protected from hyperinsulinemia and glucose intolerance despite obesity when placed on a HF diet.

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John J Kopchick Research Topics

Disease

44	Insulin Resistance 01/2022 - 01/2004
21	Neoplasms (Cancer) 01/2022 - 09/2003
16	Body Weight (Weight, Body) 09/2021 - 02/2003
13	Obesity 10/2018 - 09/2004
11	Acromegaly 01/2021 - 01/2006
7	Inflammation (Inflammations) 11/2020 - 11/2012
7	Hyperinsulinism (Hyperinsulinemia) 06/2019 - 04/2007
6	Laron Syndrome (Syndrome, Laron) 01/2022 - 09/2004
6	Weight Loss (Weight Reduction) 01/2022 - 05/2007
5	Fibrosis (Cirrhosis) 02/2022 - 01/2017
5	Carcinogenesis 01/2022 - 12/2005
5	Glucose Intolerance 07/2021 - 07/2009
5	Melanoma (Melanoma, Malignant) 12/2020 - 11/2013
4	Type 2 Diabetes Mellitus (MODY) 07/2015 - 09/2005
3	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 12/2005
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 07/2021 - 10/2009
3	Hyperglycemia 06/2019 - 09/2005
3	Hypertrophy 01/2018 - 06/2005
3	Frailty 04/2016 - 04/2009
3	Hyperplasia 01/2007 - 09/2003
2	Dwarfism 01/2022 - 03/2005
2	Abdominal Obesity 01/2022 - 05/2007
2	Premature Aging 01/2022 - 09/2011
2	Hypoxia (Hypoxemia) 01/2022 - 01/2019
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 03/2005
2	Growth Disorders 01/2021 - 01/2006
2	Hypoglycemia (Reactive Hypoglycemia) 11/2019 - 01/2013
2	Kidney Diseases (Kidney Disease) 10/2019 - 11/2005
2	Pituitary Neoplasms (Pituitary Adenoma) 06/2019 - 07/2011
2	Muscular Atrophy (Muscle Atrophy) 01/2017 - 12/2004
2	Weight Gain 12/2014 - 06/2006
2	Carcinoma (Carcinomatosis) 08/2006 - 12/2005
1	Muscular Diseases (Myopathy) 01/2022
1	Cognitive Dysfunction 01/2022
1	Chagas Disease (American Trypanosomiasis) 01/2022
1	Metabolic Diseases (Metabolic Disease) 01/2022
1	Cushing Syndrome 01/2022
1	Hyperphagia (Overeating) 12/2019
1	Diabetic Nephropathies (Diabetic Nephropathy) 10/2019
1	Intestinal Diseases (Diseases, Intestinal) 06/2019
1	Lipodystrophy 01/2018
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2017
1	Atrophy 01/2017
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017
1	Alzheimer Disease (Alzheimer's Disease) 01/2017

Drug/Important Bio-Agent (IBA)

45	Growth Hormone (Somatotropin)IBA 01/2022 - 01/2004
25	Insulin (Novolin)FDA Link 01/2022 - 09/2003
24	Insulin-Like Growth Factor I (IGF-1)IBA 01/2022 - 09/2003
18	Somatotropin Receptors (Growth Hormone Receptor)IBA 01/2022 - 09/2003
17	Glucose (Dextrose)FDA LinkGeneric 09/2021 - 01/2004
13	Proteins (Proteins, Gene)FDA Link 06/2019 - 09/2005
8	Insulin-Like PeptidesIBA 01/2022 - 11/2005
7	Blood Glucose (Blood Sugar)IBA 01/2022 - 01/2004
7	LeptinIBA 01/2022 - 02/2006
7	LipidsIBA 01/2018 - 11/2005
6	Biomarkers (Surrogate Marker)IBA 01/2019 - 06/2010
5	AdiponectinIBA 01/2019 - 08/2004
5	Messenger RNA (mRNA)IBA 01/2018 - 12/2004
5	Hormones (Hormone)IBA 12/2015 - 09/2004
5	ProlactinIBA 08/2010 - 09/2003
4	Deoxyglucose (2 Deoxy D glucose)IBA 01/2022 - 11/2019
4	Pharmaceutical PreparationsIBA 12/2020 - 04/2014
3	pegvisomant FDA LinkGeneric 01/2022 - 01/2011
3	CytokinesIBA 11/2020 - 11/2012
3	Carrier Proteins (Binding Protein)IBA 03/2017 - 01/2007
3	AdipokinesIBA 01/2017 - 01/2014
2	bovine growth hormoneIBA 02/2022 - 11/2020
2	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2022 - 12/2004
2	GhrelinIBA 09/2021 - 02/2006
2	Prolactin Receptors (Prolactin Receptor)IBA 01/2020 - 12/2007
2	Transcription Factors (Transcription Factor)IBA 09/2019 - 05/2006
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 09/2019 - 01/2017
2	MyostatinIBA 01/2018 - 01/2017
2	CollagenIBA 01/2018 - 08/2010
2	Small Interfering RNA (siRNA)IBA 03/2017 - 01/2017
2	ProteomeIBA 01/2017 - 10/2011
2	salicylhydroxamic acid (SHAM)IBA 01/2017 - 01/2007
2	Prealbumin (Transthyretin)IBA 01/2014 - 06/2010
2	Protein Isoforms (Isoforms)IBA 01/2014 - 06/2010
2	Blood Proteins (Serum Proteins)IBA 03/2013 - 06/2010
2	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2011 - 01/2006
2	Fatty Acids (Saturated Fatty Acids)IBA 05/2007 - 03/2005
1	RNA (Ribonucleic Acid)IBA 01/2022
1	Volatile Fatty AcidsIBA 01/2022
1	GlucocorticoidsIBA 01/2022
1	Human Growth Hormone (Saizen)FDA LinkGeneric 01/2021
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2020
1	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 12/2019
1	LigandsIBA 06/2019
1	Receptor for Advanced Glycation End ProductsIBA 06/2019
1	Leukocyte L1 Antigen Complex (Calgranulin)IBA 06/2019
1	Agouti-Related ProteinIBA 01/2019
1	Triglycerides (Triacylglycerol)IBA 01/2019
1	Adrenergic Agents (Adrenergic Drugs)IBA 10/2018
1	Cre recombinaseIBA 10/2018
1	Sirolimus (Rapamycin)FDA Link 01/2018
1	XenobioticsIBA 01/2017
1	Insulin ReceptorIBA 01/2017

Therapy/Procedure

8	Therapeutics 01/2020 - 08/2010
3	Injections 01/2022 - 01/2013